Endocrine Abstracts

Oestrogens act via oestrogen receptors (ER) that are expressed in a wide range of tissues including the vasculature, bone and gonads. Two ER genes known as ERalpha and ERbeta have been identified. In the human splice variants of ERbeta have been identified. ERs form both homodimers and heterodimers upon ligand binding. The aim of the present experiments was to study the functional activity of ERbeta1 (wild type) and ERbeta variant (ERbeta2) in single and double transfection as...